Toward realistic virtual surgical simulation : using heuristically parameterized anisotropic mass-spring model to simulate tissue mechanical responses

2009-2010 > Academic research: refereed > Refereed conference paperAccepted ManuscriptPublishe

A Transfer-Based Additive LS-SVM Classifier for Handling Missing Data

IEEE The performance of a classifier might greatly deteriorate due to missing data. Many different techniques to handle this problem have been developed. In this paper, we solve the problem of missing data using a novel transfer learning perspective and show that when an additive least squares support vector machine (LS-SVM) is adopted, model transfer learning can be used to enhance the classification performance on incomplete training datasets. A novel transfer-based additive LS-SVM classifier is accordingly proposed. This method also simultaneously determines the influence of classification errors caused by each incomplete sample using a fast leave-one-out cross validation strategy, as an alternative way to clean the training data to further improve the data quality. The proposed method has been applied to seven public datasets. The experimental results indicate that the proposed method achieves at least comparable, if not better, performance than case deletion, mean imputation, and k-nearest neighbor imputation methods, followed by the standard LS-SVM and support vector machine classifiers. Moreover, a case study on a community healthcare dataset using the proposed method is presented in detail, which particularly highlights the contributions and benefits of the proposed method to this real-world application

Controlled release of human growth hormone fused with a human hybrid Fc fragment through a nanoporous polymer membrane

Nanotechnology has been applied to the development of more effective and compatible drug delivery systems for therapeutic proteins. Human growth hormone (hGH) was fused with a hybrid Fc fragment containing partial Fc domains of human IgD and IgG(4) to produce a long-acting fusion protein. The fusion protein, hGH-hyFc, resulted in the increase of the hydrodynamic diameter (ca. 11 nm) compared with the diameter (ca. 5 nm) of the recombinant hGH. A diblock copolymer membrane with nanopores (average diameter of 14.3 nm) exhibited a constant release rate of hGH-hyFc. The hGH-hyFc protein released in a controlled manner for one month was found to trigger the phosphorylation of Janus kinase 2 (JAK2) in human B lymphocyte and to exhibit an almost identical circular dichroism spectrum to that of the original hGH-hyFc, suggesting that the released fusion protein should maintain the functional and structural integrity of hGH. Thus, the nanoporous release device could be a potential delivery system for the long-term controlled release of therapeutic proteins fused with the hybrid Fc fragment.X111313sciescopu

Radiographic condylar changes following vertical subsigmoid osteotomy in different setback magnitudes

Meeting Theme: The Future of Stem Cell Research in Clinical DentistryPoster Abstracts: P-01OBJECTIVES: The objective of this retrospective study was to compare the effect of different mandibular setback amount by vertical subsigmoid osteotomy (VSSO) on the pattern of radiographic condylar remodeling in one year time span post-surgically. Methods: 200 patients diagnosed of mandibular prognathism and underwent VSSO surgery with various setback amounts from 2007 until 2012 at the Prince Philip Dental Hospital were included in this study. Pre-surgical and 1 year post-surgical Postero-Anterior Cephalogram, Lateral Cephalograms and Cone Beam Computed Tomography (CBCT) Scans were retrieved. Tracings of plain cephalometric radiographs were performed. CBCT data sets were used to measure the linear and condylar axis angle value in multiplanar view. Finally the pre- and post-surgical 3D condyle-ramus units were superimposed using stable registration point of the condylar neck and ramal area above the lingula to assess the condylar bone remodeling by ...postprin

Integrating PhysX and OpenHaptics : efficient force feedback generation using physics engine and haptic devices

2009-2010 > Academic research: refereed > Refereed conference paperAccepted ManuscriptPublishe

A Study of Initialization in Linux and OpenBSD

The code that initializes a system can be notoriously difficult to understand. In secure systems, initialization is critical for establishing a starting state that is secure. This paper explores two architectures used for bringing an operating system to its initial state, once the operating system gains control from the boot loader. Specifically, the ways in which the OpenBSD and Linux operating systems handle initialization are dissected

CMS endcap RPC gas gap production for upgrade

The CMS experiment will install a RE4 layer of 144 new Resistive Plate Chambers (RPCs) on the existing york YE3 at both endcap regions to trigger high momentum muons from the proton-proton interaction. In this paper, we present the detailed procedures used in the production of new RPC gas gaps adopted in the CMS upgrade. Quality assurance is enforced as ways to maintain the same quality of RPC gas gaps as the existing 432 endcap RPC chambers that have been operational since the beginning of the LHC operation

First report of Perkinsus honshuensis in the variegated carpet shell clam Ruditapes variegatus in Korea

The recent discovery of Perkinsus honshuensis, a new Perkinsus species infecting Manila clams Ruditapes philippinarum (Sowerby, 1852), in Japan, suggested that, based on proximity, P. honshuensis could also be in Korean waters, where to date, P. olseni was believed to be the only Perkinsus species present. Perkinsus sp. infections consistently occurred among Ruditapes variegatus clams on a pebble beach on Jeju Island, off the south coast of Korea. The typical \u27signet ring\u27 morphology of the parasite was observed in the connective tissue of the digestive gland, and infection intensity was comparatively low (3.3 x 10(3) +/- 1.2 x 10(4) to 1.3 x 10(4) +/- 6.1 x 10(4) cells g(-1) gill weight). Further DNA analyses of internal transcribed spacer (ITS-1, 5.8S and ITS-2) and non-transcribed spacer (NTS) regions of the parasite showed 98.9-99.8 and 98.5-99.5% similarity to those of P. honshuensis from Japan, respectively. Phylogenetic analyses using ITS and NTS sequences indicated that Perkinsus sp. from Jeju formed a highly supported clade with P. honshuensis. This is the first report of P. honshuensis infections in clams in Korean waters and the first report of R. variegatus as a host for that parasite

A virtual training simulator for learning cataract surgery with phacoemulsification

Author name used in this publication: Fu-Lai Chung2009-2010 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

A virtual psychiatric ward for orientating patients admitted for the first time

2010-2011 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe